Andrej Sali Lab

Our Resources

Bioinformatics, Computational Structural Biology

We are using computation grounded in the laws of physics and evolution to study the structure and function of proteins. We aim to improve and apply methods for:

predicting the structures of proteins;
determining the structures of macromolecular assemblies;
annotating the functions of proteins using their structures.

This research enhances the impact of genome sequencing, structural genomics, and functional genomics on biology and medicine.

News

Congratulations to Keren:
The paper "Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach", K. Lasker, et al, has been accepted for publication in PNAS !

Congratulations to Riccardo on the news of his Swiss National Science Foundation fellowship!!

Congratulations to Avner:
The paper "Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET", A. Schlessinger, E. Geier, H. Fan, J. Irwin, B. Shoichet, K. Giacomini, A. Sali, has been accepted for publication in PNAS !

Congratulations to Peter on being awarded the Howard Hughes Medical Institutes Predoctoral Fellowship!!

Congratulations Charles on being awarded the NSF Graduate Research Fellowship!!

Congratulations to Dave:
D. Barkan, D. Hostetter, S. Mahrus, U. Pieper, J. Wells, C. Craik, A. Sali. Prediction of Protease Substrates using Sequence and Structure Features. Bioinformatics 26, 1714-1722, 2010.

The Chimera - Modeller module is now available in the daily builds of UCSF Chimera!

Congratulations Peter on being awarded a 2010-11 Chancellor's Graduate Research Fellowship!!

Selected Publications

F. Alber, S. Dokudovskaya, L. Veenhoff, W. Zhang, J. Kipper, D. Devos, A. Suprapto, O. Karni, R. Williams, B.T. Chait, M.P Rout, A. Sali. "Determining the architectures of macromolecular assemblies" Nature 450, 683-694, 2007.
C.V. Robinson, A. Sali, W. Baumeister. "Molecular sociology of the cell" Nature 450, 973-982, 2007.
T. Schwede, A. Sali, B. Honig, M. Levitt, H.M. Berman et al "Outcome of a workshop on applications of protein models in biomedical research." Structure 17, 151-159, 2009.
K. Lasker, M. Topf, A. Sali, H. Wolfson. Inferential optimization for simultaneous fitting of multiple components into a cryoEM map of their assembly. Journal of Molecular Biology 388, 180-194, 2009.

Gallery